Allantoin was originally named after the allantois, an embryonic excretory organ, in which it is localized during the development of most mammals with the exception of humans. This compound is formed from the oxidation of uric acid through purine catabolism. Shortly after birth, Allantoin is the main chemical compound that excretes nitrogenous waste from the body.
Allantoin is also found in the botanical extracts of some plants, including the comfrey plant of the genus Symphytum, which is used as both a fertilizer and as an herbal medicine. Synthetically-made Allantoin is analogous to naturally found Allantoin, and it is safe, non-toxic and compatible with many cosmetic raw materials.
After discovering the many anti-aging and antioxidant benefits of Allantoin from the plant root of Comfrey, chemists looked at combining Allantoin with Ascorbic Acid, or Vitamin C. Ascorbic Acid had been known to prevent and treat scurvy, as well as possesses antioxidant properties for fats and oils. The two ingredients were mixed in a dry state, added to a water mixture, and then dried. This compound, namely Allantoin Ascorbate, is now a widely used salt complex with many moisturizing and anti-irritant properties.